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Clinicopathologic features and predictors for survival of mucinous and non-mucinous appendiceal adenocarcinoma
Jun-Te Hsu1, Han-Ming Chen, Chien-Hung Liao
1Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC.
Background/Aims:
We report a study in patients with mucinous and non-mucinous appendiceal adenocarcinoma treated surgically whose records were examined to elucidate their clinicopathologic features and prognostic factors for survival.
Methods:
The medical records of 34 patients with mucinous and non-mucinous appendiceal adenocarcinoma (1991-2005) were retrospectively reviewed.
Results:
There was no significant difference between mucinous and non-mucinous tumors in patient demographics, clinicopathologic features, type of operation and outcome. Non-mucinous tumors had a higher incidence of leukocytosis than mucinous ones. The overall 5-year survival rate for 34 patients with appendiceal adenocarcinoma was 35.8%. In the univariate analysis, predictors of survival were the type of operation, resectability, carcinomatosis and tumor stage. Tumor stage significantly influenced patient survival in the multivariate analysis.
Conclusion:
Mucinous appendiceal adenocarcinoma had clinicopathologic characteristics and a prognosis similar to non-mucinous, except that there was more leukocytosis in non-mucinous tumors. Tumor stage is an independent predictor for survival among patients with appendiceal adenocarcinoma.
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