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Related Experiment Videos

Elevated urinary C-peptide excretion in multiple trauma patients.

M Jeevanandam1, L Ramias, W R Schiller

  • 1Trauma Center, St. Joseph's Hospital & Medical Center, Phoenix, Arizona 85013.

The Journal of Trauma
|March 1, 1991
PubMed
Summary

Severely injured patients show increased C-peptide and insulin secretion, suggesting trauma enhances insulin output. Parenteral feeding further boosts C-peptide and catecholamine excretion, peaking on day four.

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Area of Science:

  • Metabolic responses to trauma
  • Endocrinology
  • Biochemistry

Background:

  • C-peptide measurement is an indirect method for estimating insulin secretion.
  • Severe injury leads to hypermetabolic and catabolic states.
  • Understanding insulin response in trauma is crucial for metabolic management.

Purpose of the Study:

  • To determine plasma C-peptide levels and daily excretion rates in multiple trauma patients.
  • To investigate the relationship between C-peptide and insulin in trauma.
  • To analyze the impact of parenteral feeding on C-peptide and catecholamine excretion.

Main Methods:

  • Measurement of plasma C-peptide and insulin levels.
  • Analysis of 24-hour urine C-peptide excretion.

Related Experiment Videos

  • Correlation analysis between C-peptide and insulin.
  • Monitoring changes during 6-day parenteral feeding.

    • Main Results:

    • Plasma C-peptide to insulin ratio was similar to controls, indicating unaltered hepatic insulin extraction.
    • C-peptide excretion was threefold higher than normal, with a twofold increase in plasma levels.
    • Parenteral feeding increased C-peptide and catecholamine excretion, peaking on day four.

    Conclusions:

    • Trauma enhances C-peptide and insulin secretion, not due to insulin resistance from decreased secretion.
    • Increased insulin output is a desirable response to support an anabolic stimulus during catabolism.
    • Parenteral nutrition influences the excretion patterns of C-peptide and catecholamines.