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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: Jun 28, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Progress & prospects: gene therapy in aging.

S I S Rattan¹, R Singh

¹Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark. rattan@mb.au.dk

|November 14, 2008

Summary

This summary is machine-generated.

Genetic interventions show promise for extending lifespan in model organisms by altering gene expression. However, human application faces challenges due to complex genetic and epigenetic interactions affecting longevity.

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Last Updated: Jun 28, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

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Published on: February 4, 2021

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Area of Science:

Genetics
Longevity Research
Molecular Biology

Background:

Genetic interventions in model systems can increase lifespan.
These interventions often involve gene silencing or overexpression.
Known roles of targeted genes in metabolic processes.

Purpose of the Study:

To explore the potential of genetic interventions for increasing longevity.
To investigate the applicability of genetic modifications to human lifespan.
To understand the interplay between genetics, epigenetics, and aging.

Main Methods:

Review of studies on genetic interventions in experimental models.
Analysis of gene polymorphisms associated with human longevity.
Consideration of epigenetic factors influencing lifespan.

Main Results:

Gene manipulation (silencing/overexpression) extends longevity in model systems.
Studies identify age-associated gene and haplotype frequencies.
Human application of genetic interventions is complex.
Epigenetic factors significantly influence life course and span.

Conclusions:

Genetic interventions offer potential longevity benefits but require careful consideration of side effects.
Human longevity is influenced by a complex interplay of genetic and epigenetic factors.
Genetic redesigning for human longevity remains a significant challenge.