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Updated: Jun 28, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Molecular recognition through divalent interactions with a self-assembled fibrillar network of a supramolecular
Beatriu Escuder1, Juan F Miravet, José A Sáez
1Departament de Química Inorgànica i Orgànica; Universitat Jaume I, 12071, Castelló, Spain. escuder@uji.es
Abstract:
The interaction of phenol derivatives with the self-assembled fibrillar network of two different supramolecular gels has been studied. NMR relaxometry reveals the selective interaction of resorcinol over other related molecules with a gel formed by the gelator 2 which contains terminal pyridine units. No selectivity is observed for a related gelator that contains phenyl instead of pyridine moieties. The selectivity observed by NMR experiments permits the selective suppression of the 1H NMR signals of resorcinol. This behaviour is translated to macroscopic properties such as the thermal stability of the gels. The observed selectivity together with X-ray diffraction data and molecular modelling suggest that the gels formed by 2 present arrays of pyridine H-bond acceptor groups capable of selective multivalent interaction with phenolic substrates.
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