Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section.

JOR spine·2026
Same author

Outpatient management of women with preterm prelabour rupture of the membranes: A retrospective multicentre cohort study.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation.

NPJ Regenerative medicine·2025
Same author

Socioeconomic Area Deprivation is Related to Poorer Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI).

Cartilage·2025
Same author

Performance and potential utility of the BioFire Joint Infection Panel with synovial fluid and joint tissue specimens.

Journal of clinical microbiology·2025
Same author

Increased synovitis and pro-inflammatory macrophage abundance are observed in the synovia of patients at risk of developing post-traumatic OA compared to those with established OA.

Osteoarthritis and cartilage open·2025
Same journal

Osteoporosis-related knowledge in a German adult population: determinants and translational implications for fragility fracture prevention.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Evaluating differences in the upper instrumented vertebra (UIV) tilt angle between adolescent idiopathic scoliosis patients with Lenke 1-ve (flexible) and Lenke 1 +ve (stiff) curves.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Scoping review: artificial intelligence in patient education for scoliosis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Cement leakage and post-operative outcomes after lower-versus higher-volume bone cement injection in percutaneous vertebroplasty: a systematic review and meta-analysis of randomized controlled trials.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Incidence and predictors of early and late reoperation after primary lumbar spine fusion: a 10-year retrospective cohort study of 1,356 patients.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Mechanism of Netrin-1 in electroacupuncture-mediated inhibition of nerve fiber ingrowth in degenerative intervertebral discs.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Tissue engineering and the intervertebral disc: the challenges.

Rita Kandel1, Sally Roberts, Jill P G Urban

  • 1CIHR-Bioengineering of Skeletal Tissues Team, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. rkandel@mtsinai.on.ca

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|November 14, 2008
PubMed
Summary
This summary is machine-generated.

Degenerative disc disease causes significant costs and pain. Regenerative medicine and tissue engineering offer promising new treatments, but clinical application faces challenges.

More Related Videos

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model
07:06

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model

Published on: October 10, 2025

Related Experiment Videos

Last Updated: Jun 28, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model
07:06

Surgical Technique for the Implantation of a Biomimetic Artificial Intervertebral Disc in a Goat Animal Model

Published on: October 10, 2025

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Degenerative disc disease (DDD) is a prevalent condition causing substantial morbidity and economic burden.
  • Current surgical treatments for DDD focus on tissue removal, with limited long-term efficacy.
  • There is a critical need for novel therapeutic strategies to address symptomatic DDD.

Purpose of the Study:

  • To review the challenges hindering the clinical application of regenerative medicine and tissue engineering for disc degeneration.
  • To highlight the potential of these advanced approaches in treating DDD.

Main Methods:

  • Literature review of current research in regenerative medicine and tissue engineering for disc degeneration.
  • Analysis of existing barriers to clinical translation.

Main Results:

  • Regenerative medicine and tissue engineering present a promising paradigm shift for DDD treatment.
  • Significant challenges remain in areas such as cell sourcing, scaffold development, and in vivo integration.
  • Overcoming these hurdles is essential for successful clinical implementation.

Conclusions:

  • Novel regenerative approaches hold great promise for treating disc degeneration.
  • Addressing current limitations in tissue engineering is crucial for effective clinical application.
  • Further research and development are needed to realize the full potential of these therapies.