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Related Experiment Video

Updated: Jun 28, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development
04:37

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Published on: June 16, 2023

Left ventricular long-axis function in treated haemochromatosis.

Einar Skulstad Davidsen1, Tor Hervig, Per Omvik

  • 1Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. einar.davidsen@helse-bergen.no

The International Journal of Cardiovascular Imaging
|November 14, 2008
PubMed
Summary
This summary is machine-generated.

Genetic haemochromatosis patients show normal resting long-axis cardiac function. However, treatment influences systolic (S’) and early diastolic (E’) velocities, indicating subtle cardiac changes in treated haemochromatosis.

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Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Genetic Medicine

Background:

  • Reduced exercise capacity is observed in treated genetic haemochromatosis patients.
  • Radial left ventricular (LV) systolic function is typically normal at rest in these patients.
  • The impact of haemochromatosis on LV long-axis function at rest is not well understood.

Purpose of the Study:

  • To assess resting LV long-axis function in treated genetic haemochromatosis patients.
  • To investigate potential differences in systolic (S') and early diastolic (E') velocities between patients and controls.
  • To identify factors associated with LV long-axis function in haemochromatosis.

Main Methods:

  • Echocardiography with spectral tissue Doppler was used to measure S' and E' velocities.
  • 105 treated haemochromatosis patients and 50 controls were included in the study.
  • Multiple regression and multivariate analyses were performed to identify associated factors.

Main Results:

  • LV long-axis function was normal in the haemochromatosis group.
  • Systolic velocity (S') was significantly higher in patients compared to controls.
  • Lower early diastolic velocity (E') was associated with haemochromatosis, independent of other factors.

Conclusions:

  • Treated genetic haemochromatosis influences both systolic and early diastolic LV long-axis function, despite overall normal function.
  • Higher systolic velocity (S') and lower early diastolic velocity (E') are associated with haemochromatosis.
  • These findings suggest subtle cardiac alterations in treated haemochromatosis patients.