Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
Types of Limits I01:23

Types of Limits I

Limits are a key mathematical concept for understanding how functions behave as their input approaches specific values, particularly when the function is undefined. They help reveal trends and discontinuities by examining the values a function approaches rather than its actual value.One-sided limits focus on the direction from which a value is approached. When a function behaves differently depending on whether the input approaches from the left or the right, the two one-sided limits may not...
The Precise Definition of a Limit01:27

The Precise Definition of a Limit

Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for every ε >...
Limits of Multivariable Functions01:25

Limits of Multivariable Functions

Limits of multivariable functions describe how a function behaves as its input approaches a particular point in the plane. In single-variable calculus, a limit examines the behavior of a function as the input approaches a number from two directions along a line. For functions of two variables, the situation is more complex because the input can approach a point from infinitely many paths in the xy-plane. A limit exists only when the function approaches the same value along every possible...
Introduction to Limits01:30

Introduction to Limits

A limit describes the value a function approaches as its input moves closer to a particular point. Even when a function is undefined at a specific value, limits allow us to analyze its behavior near that point. This concept is fundamental in calculus and essential for understanding continuity, derivatives, and integrals.Mathematically, a function f(x) has a limit L at x = a if its values L approach x as x gets arbitrarily close to a. This is written as:This notation expresses that the function...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evaluation of pesticides and their primary toxic degradation products in drinking water from the viewpoint of human toxicology: Is it adequate?

Environmental science and pollution research international·2013
Same author

[Threshold values, guiding values, benchmarks, action values: definitions and determination with examples from the UBA].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2009
Same author

[Toxicological and drinking water hygienic assessment of relevant and nonrelevant metabolites from pesticides in ground and drinking water].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2009
Same author

Environmental hygiene and management of chemicals.

Environmental science and pollution research international·2008
Same author

Re: Ritter, Leonard, Totman, Celine, Krishnan, Kannan, Carrier, Richard, Vezina, Anne, Morisset, Veronique. (2007). Deriving uncertainty factors for threshold chemical contaminants in drinking water. Journal of Toxicology and Environmental Health, Part B, 10:527-557.

Journal of toxicology and environmental health. Part B, Critical reviews·2008
Same author

[What is the understanding of the scientific basis and the regulatory toxicology associated with the term "not appreciable " in the risk evaluation of carcinogens].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2007
Same journal

Mineralogical characterization of tobacco stalk ash.

Environmental science and pollution research international·2026
Same journal

Occurrence, distribution and risk assessment of pharmaceuticals and personal care products in Djibouti aquifer.

Environmental science and pollution research international·2026
Same journal

Anthropogenic microparticles and mercury co-occurrence in blue sharks from the Tropical Eastern Pacific.

Environmental science and pollution research international·2026
Same journal

IoT-enabled FMIND pipeline with chemical validation for microplastic contamination risk assessment in bottled water under varying storage conditions.

Environmental science and pollution research international·2026
Same journal

Retraction Note: Toward a sustainable environment: nexus between geothermal energy growth and land use change in EU economies.

Environmental science and pollution research international·2026
Same journal

Retraction Note: COVID-19: pathogenesis, advances in treatment and vaccine development and environmental impact-an updated review.

Environmental science and pollution research international·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification
09:04

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Published on: August 17, 2015

Defining proactive limit values.

H H Dieter1

  • 1Institute for Water, Soil and Air Hygiene of the Federal Environmental Agency, P.O. Box 330022, D-14191, Berlin, Germany.

Environmental Science and Pollution Research International
|November 14, 2008
PubMed
Summary
This summary is machine-generated.

The Basic Rule of Environmental Hygiene (BREH) provides a framework for proactive chemical management. It defines acceptable exposure levels for different substance groups to ensure environmental safety and minimize adverse effects.

Related Experiment Videos

Last Updated: Jun 28, 2026

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification
09:04

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification

Published on: August 17, 2015

Area of Science:

  • Environmental Science
  • Toxicology
  • Risk Assessment

Background:

  • Chemical management requires proactive strategies to mitigate environmental and health risks.
  • Existing frameworks may not adequately address diverse exposure scenarios.
  • The Basic Rule of Environmental Hygiene (BREH) offers a foundational approach.

Purpose of the Study:

  • To derive proactive limit values (LVs) for chemicals based on the BREH.
  • To establish a systematic approach for chemicals management aligned with environmental hygiene principles.
  • To explore the BREH's utility in sustainable chemical management and societal risk reduction.

Main Methods:

  • Derivation of three distinct proactive limit value (LV) definitions from the BREH.
  • Categorization of exposure based on functionality: functional residues (Group B), non-functional contaminants (Group C), and natural exposure (Group A).
  • Application of thresholds (FB, Tc) and adverse effect levels (Ea) to define acceptable exposure ranges for each group.

Main Results:

  • LVB definition: Functional residues (Group B) accepted above a technical threshold (FB > 0) but below adverse effect levels (LVB < Ea).
  • LVC definition: Non-functional contaminants (Group C) tolerated at minimal or zero technical levels (Fc = 0, Tc), below adverse effect levels (LVC ≤ Ea).
  • LVA definition: Natural exposure (Group A) accepted up to its natural upper limit (NA ≤ Ea), regardless of safety margin.

Conclusions:

  • The BREH serves as a robust starting point for establishing proactive chemical limit values.
  • This approach supports sustainable environmental care and responsible chemical management.
  • The BREH framework can facilitate consensus among stakeholders to minimize societal adverse effects.