Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear nucleus cell size is regulated by auditory nerve electrical activity.

T R Pasic1, E W Rubel

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle 98195.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity.

Neuroscience·2008
Same author

FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia.

Developmental biology·2002
Same author

Accommodation enhances depolarizing inhibition in central neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Characterization of damage and regeneration in cultured avian utricles.

Journal of the Association for Research in Otolaryngology : JARO·2001
Same author

Tonotopic map of potassium currents in chick auditory hair cells using an intact basilar papilla.

Hearing research·2001
Same author

Visual influences on the development and recovery of the vestibuloocular reflex in the chicken.

Journal of neurophysiology·2001

Sensorineural hearing loss causes central auditory neuron shrinkage. However, blocking auditory nerve activity with tetrodotoxin for 24 hours showed reversible cell size changes in gerbils after a 7-day recovery period.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Cell Biology

Background:

  • Sensorineural hearing loss leads to rapid degenerative changes in central auditory neurons.
  • Cochlear removal or pharmacologic blockade of auditory nerve activity causes a decrease in central auditory neuron cell size.

Purpose of the Study:

  • To investigate the reversibility of central auditory changes following profound sensorineural hearing loss induced by blocking auditory nerve action potentials.

Main Methods:

  • Profound sensorineural hearing loss was induced in gerbils using tetrodotoxin, a sodium channel blocker, delivered via a slow-release vehicle near the round window membrane.
  • Auditory nerve electrical activity was unilaterally blocked for 24, 48 hours, or continuously for 24 hours.
  • Cell size of large spherical cells in the anteroventral cochlear nucleus was measured ipsilaterally and contralaterally.

Related Experiment Videos

Main Results:

  • A 24-hour blockade of auditory nerve electrical activity resulted in a 16% mean decrease in ipsilateral cell size.
  • Following a 7-day recovery period after 24 or 48 hours of blockade, cell size returned to baseline levels.
  • No significant difference in cell size was observed between the manipulated and unmanipulated sides of the brain after the recovery period.

Conclusions:

  • Central auditory neuron changes induced by acute sensorineural hearing loss are reversible.
  • Transient blockade of auditory nerve activity does not cause permanent degenerative changes in central auditory neurons.