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Electropreconcentration with charge-selective nanochannels.

Adrien Plecis¹, Clément Nanteuil, Anne-Marie Haghiri-Gosnet

¹Laboratoire de Photonique et Nanostructures, CNRS, 91460 Marcoussis, France. adrien.plecis@lpn.cnrs.fr

Analytical Chemistry

|November 14, 2008

Summary

Electropreconcentration in micro/nanofluidic devices shows four distinct regimes due to competing electroosmotic and electrophoretic forces. Species mobility and valence significantly impact preconcentration rates.

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Area of Science:

Microfluidics and Nanofluidics
Electrokinetics
Molecular Transport Phenomena

Background:

Electropreconcentration is a key technique for concentrating charged molecules.
Understanding the underlying forces is crucial for optimizing device performance.
Hybrid micro/nanofluidic systems offer unique environments for studying these phenomena.

Purpose of the Study:

To systematically investigate electropreconcentration in hybrid micro/nanofluidic devices.
To identify and classify different preconcentration regimes.
To elucidate the role of electrokinetic forces and molecular properties.

Main Methods:

Systematic experimental investigation of electropreconcentration.
Numerical calculations of spatiotemporal concentration of charged molecules.
Analysis of electroosmotic and electrophoretic forces, including polarization effects.

Main Results:

Identified four distinct electropreconcentration regimes.
Regimes occur at both cathodic and anodic sides of the nanochannel.
Numerical simulations align with experimental data at low/moderate ionic strengths.
Demonstrated the influence of species mobility and valence on preconcentration rates.

Conclusions:

The interplay between electroosmotic drag and nonlinear electrophoretic forces governs preconcentration.
Four distinct regimes are confirmed through numerical and experimental validation.
Molecular properties are critical factors for controlling preconcentration efficiency in these devices.