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Inflammation and the glutamate system in schizophrenia: implications for therapeutic targets and drug development
1Ludwig-Maximilians-University, Hospital for Psychiatry and Psychotherapy, Nussbaumstr 7, 80336 Munich, Germany. Norbert.Mueller@med.uni-muenchen.de
Background:
Despite the progress in antipsychotic therapy for schizophrenia, the effects are still not satisfactory. There is a high percentage of therapy-resistant patients and the overall course of the disease is unfavourable in many affected individuals. Therefore, other therapeutic targets than dopaminergic and serotonergic neurotransmitters are being considered.
Objective:
Glutamatergic hypofunction, mediated mainly by NMDA receptor blockade, is suggested to be indirectly responsible for dopaminergic dysfunction in schizophrenia. Increased levels of kynurenic acid (KYN-A), an endogenous NMDA receptor antagonist, resulting from disturbed tryptophan/kynurenine metabolism can explain psychotic symptoms and cognitive deterioration.
Methods:
The role of the immune system in the production of KYN-A and therapeutic targets in the immune and glutamate systems are outlined.
Conclusions:
Therapeutic consequences are discussed. Glutamate modulators that particularly influence the NMDA co-transmitters glycine and serine, including inhibitors of glycine transporters, are described and initial clinical evidence is discussed. Another target of the glutamate system is the metabotropic mGlu2/3 receptor; Preliminary clinical results of a study with a mGlu2/3 receptor agonist in schizophrenia are mentioned.
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