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The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
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Current and emerging paradigms in the therapeutic management of atherosclerosis

Atul Tiwari1

  • 1Jubilant Biosys Ltd., CardioMetabolic Disorder Group, Drug Discovery Unit-Biology, #96, 2nd Stage, Industrial Suburb, Yeshwantpur, Bangalore-560022, Karnatka, India. atul_tiwari@jubilantbiosys.com

Expert Opinion on Therapeutic Targets
|November 15, 2008
PubMed
Abstract

Insights

Recent drug discovery setbacks for atherosclerosis highlight the need for novel therapeutic targets. Emerging mechanisms offer new hope for developing effective treatments that regulate lipoprotein metabolism and inflammation.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Biochemistry

Background:

  • Atherosclerosis pathogenesis involves lipoprotein metabolism abnormalities.
  • Pathological interactions with vessel walls and inflammation exacerbate atherosclerosis.

Purpose of the Study:

  • Elucidate trends in drug discovery for atherosclerosis.
  • Identify new entities regulating lipoprotein metabolism and inflammation.

Main Methods:

  • Review of public domain research and review articles.
  • Analysis of press releases for emerging trends.

Main Results:

  • Recent drug development failures (e.g., torcetrapib) have slowed progress.
  • New therapeutic mechanisms are emerging for atherosclerosis treatment.

Conclusions:

  • Despite setbacks, new avenues for drug discovery are opening.
  • Focus on novel mechanisms targeting lipoprotein metabolism and inflammation is crucial.

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