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Related Experiment Video

Updated: Jun 28, 2026

Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse
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Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse

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Ovarian structure in mice lines selected for weight.

S F Bernardi1, G Brogliatti, M I Oyarzabal

  • 1Cátedra de Histología I y Embriología Básica, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, Ovidio Lagos y Ruta 33, 2170 Casilda, Argentina.

Anatomia, Histologia, Embryologia
|November 15, 2008
PubMed
Summary

Selecting mice for body weight significantly altered ovarian structures and reproductive efficiency. Upward selection for body weight increased ovarian follicles and corpora lutea but reduced embryo survival.

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Area of Science:

  • Animal Science
  • Reproductive Biology
  • Genetics

Background:

  • Artificial selection can impact various biological traits.
  • Body weight is a complex trait influenced by numerous genes.
  • Reproductive efficiency is crucial for animal breeding programs.

Purpose of the Study:

  • To investigate the effects of divergent selection for body weight on ovarian structures and reproductive performance in CF1 mice.
  • To compare ovarian follicle number, follicle diameter, corpora lutea, litter size, and body weight among selected and control mouse lines.

Main Methods:

  • Divergent selection for body weight at 49 days of age in CF1 mice, creating downward (s, h) and upward (s', h') selected lines.
  • Comparison with an unselected control line (Line t).

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Last Updated: Jun 28, 2026

Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse
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  • Measurement of ovarian follicle number (N), follicle diameter (FD), corpora lutea (CL), litter size (LS), and body weight (W).

    • Main Results:

    • Significant differences in N, FD, CL, LS, and W were observed among the selected and control lines.
    • Upward selected lines (s', h') showed higher N and CL compared to downward selected lines (s, h).
    • Line s' exhibited more large follicles and CL but lower embryo survival than Line h', while Line h showed reduced embryonic loss compared to Line s.

    Conclusions:

    • Selection for body weight at 49 days of age significantly modifies ovarian structures and reproductive efficiency in mice.
    • Divergent selection strategies can lead to distinct reproductive outcomes, impacting fertility and litter size.
    • Understanding these genetic correlations is vital for optimizing breeding programs in livestock and companion animals.