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The UPS in diabetes and obesity

Simon S Wing1

  • 1Polypeptide Laboratory, Division of Endocrinology and Metabolism, Department of Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, H3A 2B2, Canada. simon.wing@mcgill.ca

BMC Biochemistry
|November 26, 2008
PubMed

Insights

The ubiquitin proteasome system (UPS) impacts type 2 diabetes by degrading key insulin signaling proteins like IRS1, IRS2, and Akt. UPS dysfunction also affects insulin secretion and may contribute to obesity.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Type 2 diabetes involves impaired insulin signaling and secretion.
  • The ubiquitin proteasome system's (UPS) role in type 2 diabetes is under-explored.
  • UPS regulates protein degradation, crucial for cellular function.

Purpose of the Study:

  • To explore the involvement of the UPS in type 2 diabetes pathogenesis.
  • To identify potential drug targets within the UPS pathway for diabetes treatment.
  • To investigate UPS-mediated regulation of insulin signaling and secretion.

Main Methods:

  • Literature review of studies on UPS and type 2 diabetes.
  • Analysis of UPS-mediated degradation of key insulin signaling molecules (IRS1, IRS2, Akt).
  • Examination of UPS involvement in pancreatic beta-cell function and lipid metabolism.

Main Results:

  • UPS can induce insulin resistance by degrading IRS1, IRS2, and Akt.
  • UPS-mediated degradation of IRS2 in beta-cells may impair insulin secretion.
  • UPS influences lipid synthesis and production, potentially affecting obesity.

Conclusions:

  • The UPS plays a significant role in type 2 diabetes development.
  • UPS targets represent potential avenues for novel diabetes drug development.
  • Further research is needed on ubiquitylation's role in insulin receptor trafficking.

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