Related Experiment Video
Updated: Jun 28, 2026

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Preparation and chiral recognition of a mono[6A-N-1-(2-hydroxy)-phenylethylimino-6A-deoxy]-beta-cyclodextrin HPLC
Xiaoping Chen1, Zhiming Zhou, Hao Yuan
1School of Chemical Engineering & the Environment, Beijing Institute of Technology, Beijing100081, PR China.
Abstract:
A novel chiral stationary phase (CSP) is obtained by linking the beta-CD to a chiral block (commercially available phenylglycinol) by rigid C=N bond. This chiral stationary phase exhibites good enantioselectivity for several alkylaromatic alcohols and a variety of ferrocene derivatives under reversed-phase conditions, with the best Rs value achieve up to 6.19. The hydrogen bonding interaction may be the primary factor, also pi-pi interaction or dipole-dipole interaction has some effect on chiral separation. The dependence of the natural logarithms of retention and selectivity factors (lnk' and lnalpha) on the inverse of temperature 1/T (van't Hoff plots) is used to determine thermodynamic data referring to the separation of the enantiomers. Calculated thermodynamic constants Delta(DeltaH degrees ), Delta (DeltaS degrees ), and Delta (DeltaG degrees ) are applied to help understand of the thermodynamic driving forces for retention and enantio-recognition for this chromatographic system. It can be concluded that the separations for all the investigated analytes on this CSP are enthalpically favored.
More Related Videos
Related Concept Videos
Prochirality
High-Performance Liquid Chromatography: Introduction
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Elution Process
Stereoisomerism of Cyclic Compounds
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

