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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

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An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
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Published on: September 12, 2018

Chapter 5. Evaluating vascular leak in vivo.

Sara M Weis1

  • 1Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

Methods in Enzymology
|November 15, 2008
PubMed
Summary

Vascular permeability is crucial for wound healing and immune response but pathological leakage causes disease. Mouse models help test new therapies to control this vascular leak.

Area of Science:

  • Physiology
  • Pathology
  • Pharmacology

Background:

  • Vascular permeability is essential for normal physiology, aiding wound repair and immune cell surveillance.
  • Dysregulated vascular permeability contributes to pathologies like macular degeneration, ischemic disease, cancer, and lung injuries, leading to edema and disease exacerbation.
  • Controlling pathological vascular leak is critical for disease management and recovery.

Purpose of the Study:

  • To describe mouse models for assessing vascular permeability in vivo.
  • To evaluate novel compounds for their pro- or anti-permeability properties.
  • To investigate the role of hyperpermeability in ischemic diseases and test antileak therapies.

Main Methods:

  • Utilizing various mouse models to directly test compounds affecting vascular permeability.

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  • Employing models of ischemic disease where vascular hyperpermeability is a key factor.
  • Assessing the efficacy of potential antileak therapies in vivo.

    • Main Results:

    • Mouse models provide a platform for evaluating compounds that modulate vascular permeability.
    • These models are instrumental in dissecting molecular mechanisms of permeability regulation.
    • The described methods facilitate the development of new antileak therapies.

    Conclusions:

    • Mouse models are valuable tools for studying vascular permeability and developing therapeutic strategies.
    • Understanding and controlling pathological vascular leak is crucial for treating various diseases.
    • In vivo assessment of novel compounds and therapies is essential for advancing antileak treatments.