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Updated: Jun 28, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Cardiac remodelling and dysfunction in children with obstructive sleep apnoea: a community based study

J Y S Chan1, A M Li, C-T Au

  • 1Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. jyschan@cuhk.edu.hk

Thorax
|November 15, 2008
PubMed

Insights

Childhood obstructive sleep apnoea (OSA) is linked to heart problems. Treating OSA can reverse these cardiac changes, improving heart function in children.

Area of Science:

  • Pediatric Cardiology
  • Sleep Medicine
  • Cardiovascular Research

Background:

  • Childhood obstructive sleep apnoea (OSA) may be associated with cardiac abnormalities, but evidence is limited.
  • The impact of OSA treatment on echocardiographic outcomes requires further investigation.

Purpose of the Study:

  • To assess subclinical cardiac abnormalities in children with OSA.
  • To evaluate the effects of OSA treatment on cardiac structure and function.

Main Methods:

  • 101 children (6-13 years) underwent polysomnography (PSG) and echocardiography.
  • Children were grouped by apnoea-hypopnoea index (AHI): reference (<1), mild (1-5), and moderate-to-severe (>5).
  • Treatments included adenotonsillectomy or nasal steroids for OSA groups.

Main Results:

  • Moderate-to-severe OSA was linked to greater right ventricular (RV) systolic volume index (RVSVI), lower RV ejection fraction (RVEF), and higher RV myocardial performance index (RVMPI).
  • Significant left ventricular (LV) diastolic dysfunction and remodeling were observed in moderate-to-severe OSA.
  • Improvements in RVMPI, interventricular septal thickness index (IVSI), and E/e' were noted after AHI reduction.

Conclusions:

  • Obstructive sleep apnoea (OSA) is an independent risk factor for subclinical RV and LV dysfunction in children.
  • Improving the apnoea-hypopnoea index (AHI) is associated with the reversibility of cardiac abnormalities.
Abstract

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