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Related Experiment Video

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Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

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Published on: November 21, 2025

HDL remodeling during the acute phase response.

Anisa Jahangiri¹, Maria C de Beer, Victoria Noffsinger

¹Department of Internal Medicine, Division of Endocrinology and Molecular Medicine, University of Kentucky, Lexington, KY, USA. anisa.jahangiri@uky.edu

Arteriosclerosis, Thrombosis, and Vascular Biology

|November 15, 2008

Summary

This summary is machine-generated.

Serum amyloid A (SAA), secretory phospholipase A(2) (sPLA(2)-IIA), and cholesteryl ester transfer protein (CETP) interact to remodel HDL during the acute phase response, preserving cholesterol efflux capacity.

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Area of Science:

Biochemistry
Cardiovascular Science
Lipid Metabolism

Background:

The acute phase (AP) response involves complex changes in plasma proteins.
High-density lipoprotein (HDL) undergoes significant remodeling during the AP response.

Purpose of the Study:

To investigate the combined effects of SAA, sPLA(2)-IIA, and CETP on HDL remodeling and cholesterol efflux.
To understand HDL changes in humans following cardiac surgery during the AP response.

Main Methods:

Plasma samples were collected from patients before, and at 1 and 5 days after cardiac surgery.
SAA levels, sPLA(2)-IIA activity, and CETP mass and activity were measured.
In vitro experiments assessed the impact of SAA, sPLA(2)-IIA, and CETP on HDL remodeling and cholesterol efflux.

Main Results:

SAA levels increased 16-fold, and sPLA(2)-IIA activity significantly increased during the AP response.
CETP mass and activity decreased, correlating with reduced HDL cholesterol levels.
Combined SAA, sPLA(2)-IIA, and CETP markedly remodeled HDL, generating lipid-poor apoA-I and preserving cholesterol efflux capacity.

Conclusions:

Complex plasma protein changes during the AP response significantly remodel HDL.
This remodeling has functional implications, notably maintaining cholesterol efflux capacity.