Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Bioorganic & medicinal chemistry·2026
Same author

Discovery of Conformationally Constrained ALK2 Inhibitors.

Journal of medicinal chemistry·2024
Same author

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

ACS medicinal chemistry letters·2023
Same author

Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation.

Cell reports·2022
Same author

Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted Therapies.

Gastroenterology·2021
Same author

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.

Journal of medicinal chemistry·2020
Same journal

Downregulation of Src-family tyrosine kinases by Srcasm and c-Cbl: A comparative analysis.

Journal of carcinogenesis·2021
Same journal

Molecular classification and stratification of adult diffuse gliomas: A tertiary care center study.

Journal of carcinogenesis·2021
Same journal

Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy.

Journal of carcinogenesis·2021
Same journal

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome.

Journal of carcinogenesis·2021
Same journal

Molecular characterization of lung carcinomas: A study on diagnostic, predictive, and prognostic markers using immunohistochemical analysis at a Tertiary Care Center in Uttarakhand, India.

Journal of carcinogenesis·2021
Same journal

Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis.

Journal of carcinogenesis·2021
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach.

Brian J Wilson1

  • 1Department of Cancer Metabolism, McGill Cancer Centre, Room 715, 3655 Sir William Osler, Montréal, Québec, H3G 1Y6, Canada. Brian J. Wilson-brian.wilson2@mcgill.ca.

Journal of Carcinogenesis
|November 15, 2008
PubMed
Summary
This summary is machine-generated.

The GATA3 transcription factor coordinates diverse cellular functions across multiple tissues. This study reveals GATA3 utilizes distinct regulatory networks in different tissues, rather than a universal pathway.

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Experiment Videos

Last Updated: Jun 28, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • The GATA3 transcription factor plays crucial roles in various tissues, including the immune system, kidney, brain, endometrium, and mammary glands.
  • Its ability to coordinate diverse transcriptional programs suggests tissue-specific functions, but this has not been systematically investigated.

Purpose of the Study:

  • To systematically investigate whether GATA3 operates through conserved or distinct regulatory networks across different tissue types.
  • To identify tissue-specific pathway partners of GATA3.

Main Methods:

  • Utilized co-expression meta-analysis techniques.
  • Employed data from the Oncomine database to analyze GATA3's pathway partners.

Main Results:

  • Analysis indicates that GATA3 is involved in distinct biological pathways depending on the tissue context.
  • Identified tissue-specific regulatory networks associated with GATA3 function.

Conclusions:

  • GATA3 employs context-dependent regulatory mechanisms, utilizing different pathways in various tissues.
  • Findings provide a foundation for future research into tissue-specific GATA3 functions and therapeutic targeting.