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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

Essential role for Bclaf1 in lung development and immune system function.

J Peter McPherson1, H Sarras, B Lemmers

  • 1Department of Pharmacology, University of Toronto, Toronto, ON, Canada. peter.mcpherson@utoronto.ca

Cell Death and Differentiation
|November 15, 2008
PubMed
Summary
This summary is machine-generated.

Bcl-2 associated factor 1 (Bclaf1) is crucial for smooth muscle development in lungs and peripheral T-cell maintenance. Bclaf1-deficient cells showed no defects in apoptosis, indicating its developmental roles are independent of programmed cell death.

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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Immunology

Background:

  • Bcl-2 associated factor 1 (Bclaf1) is a nuclear protein interacting with Bcl-2 family members and Emerin.
  • Previous studies suggested Bclaf1 overexpression induces apoptosis and transcriptional repression, reversible by antiapoptotic Bcl-2 proteins.

Purpose of the Study:

  • To investigate the in vivo function of Bclaf1 using a targeted mouse mutation.
  • To determine Bclaf1's role in developmental processes and cell death.

Main Methods:

  • Generation of mice with a targeted mutation in the bclaf1 locus.
  • Analysis of lung development, thymocyte development, and peripheral T-cell homeostasis in mutant mice.
  • Assessment of cell death in Bclaf1-deficient cells under various conditions.

Main Results:

  • Bclaf1 is essential for the spatial and temporal organization of smooth muscle lineage during lung saccular development.
  • Bclaf1 is dispensable for thymocyte development but critical for peripheral T-cell homeostasis.
  • Bclaf1-deficient cells exhibited no defects in developmental or stimulus-induced apoptosis.

Conclusions:

  • Bclaf1 plays a vital role in developmental processes, particularly smooth muscle organization and T-cell homeostasis.
  • The function of Bclaf1 in development is independent of its potential role in apoptosis.