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Photo-Induced Cross-Linking of Unmodified Proteins (PICUP) Applied to Amyloidogenic Peptides
08:40

Photo-Induced Cross-Linking of Unmodified Proteins (PICUP) Applied to Amyloidogenic Peptides

Published on: January 12, 2009

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

David P Smith1, Jon Anderson, Jeffrey Plante

  • 1Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, UK LS2 9JT.

Chemical Communications (Cambridge, England)
|November 15, 2008
PubMed

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Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.