Related Experiment Video
Updated: Jun 28, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Predictors of quality of life change after an acute coronary event
Emiliane N Souza1, Alexandre S Quadros, Rúbia Maestri
1Instituto de Cardiologia do Rio Grande do Sul, Fundação Universitária de Cardiologia, Porto Alegre, RS, Brasil.
Insights
Myocardial revascularization improved quality of life (QOL) in non-ST segment elevation acute coronary syndrome patients. However, dyslipidemia predicted worse QOL scores at six months.
Area of Science:
- Cardiology
- Clinical Outcomes Research
Background:
- Quality of life (QOL) assessment is crucial for managing chronic and unstable cardiac patients.
- Key factors include functional capacity and symptom frequency (angina, etc.).
Purpose of the Study:
- Identify predictors of Quality of Life (QOL) improvement.
- Focus on patients with non-ST segment elevation acute coronary syndrome (NSTEACS).
Main Methods:
- Seattle Angina Questionnaire (SAQ) used for QOL assessment at admission and 6 months.
- Analyzed QOL score variation (6-month score minus admission score).
- Univariate and multivariate analyses compared patient characteristics and QOL improvement.
Main Results:
- Hypertension and dyslipidemia were associated with lower QOL improvement.
- Unstable angina patients showed greater QOL improvement than NSTE myocardial infarction.
- Early myocardial revascularization (within 30 days) significantly improved QOL scores.
- Dyslipidemia at baseline independently predicted worse QOL scores.
Conclusions:
- Myocardial revascularization positively impacts 6-month QOL scores in NSTEACS patients.
- Dyslipidemia is linked to poorer QOL outcomes in this population.
Background:
The assessment of quality of life (QOL), identifying functional capacity and frequency of angina and other cardiac symptoms, are key issues in the treatment of chronic patients or in those with disease instability.
Objective:
To identify predictors of quality of life (QOL) improvement in patients with non-ST segment elevation acute coronary syndrome (NSTEACS).
Methods:
Patients hospitalized in a cardiology reference hospital were assessed with the Seattle Angina Questionnaire (SAQ) at the time of admission and after 6 months. The analyzed outcome was the variation of the QOL score, resulting from the difference between the score after six months and the score at the time of admission. Differences between patients with or without 6-month QOL improvements regarding the demographic, clinical and therapeutic characteristics were assessed by univariate and multivariate analysis.
Results:
Hypertensive patients presented lower improvement in QOL scores when compared to non-hypertensive ones [8.3(0-25) vs. 16.6(0-33.3); P=0.05], as well as patients with dyslipidemia, when compared to non-dyslipidemic ones [8.3(0-25) vs. 16.6(0-33.3); P=0.02]. Patients with unstable angina presented greater improvements in QOL in relation to those with NSTE myocardial infarction [16.6(0-33.3) vs. 8.3(-8.3-25); P=0.03]. By multivariate analysis, myocardial revascularization in the first 30-days was associated with the greater improvement in the QOL score (8.47 points; P=0.005). On the other side, the presence of dyslipidemia at the baseline evaluation was an independent predictor of worse QOL scores (-7.2 points; P=0.01).
Conclusion:
Myocardial revascularization was associated with improvement in the 6-month QOL scores, while dyslipidemia was associated with worse scores.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:26Acute Coronary Syndrome V: Nursing Management
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Acute Coronary Syndrome I: Introduction
01:27Coronary Artery Disease V: Interprofessional Care