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Updated: Jun 28, 2026
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Primary tracheobronchial amyloidosis
José Wellington Alves dos Santos1, Ayrton Schneider Filho, Alessandra Bertolazzi
1Departmento de Residência Médica, Ministério da Educação, Brasília, Brazil.
Summary
Tracheobronchial amyloidosis, a rare condition causing amyloid deposits in the airways, was diagnosed in a 67-year-old man. Diagnosis required multiple bronchoscopies and Congo red staining for confirmation.
Area of Science:
- Pulmonary Medicine
- Pathology
Background:
- Tracheobronchial amyloidosis is a rare localized form of amyloidosis.
- It involves amyloid deposits exclusively in the trachea and bronchi.
Observation:
- A 67-year-old male presented with progressive dyspnea, wheezing, and chest pain.
- Symptoms were long-term and persistent.
Findings:
- Diagnosis was established after a third fiberoptic bronchoscopy.
- Histological confirmation was achieved using Congo red staining of tissue samples.
Implications:
- Highlights the diagnostic challenges of tracheobronchial amyloidosis.
- Emphasizes the importance of thorough investigation, including repeat bronchoscopies and specific staining, for rare airway diseases.
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