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Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats

Orhan Kursat Poyrazoglu1, Ibrahim Halil Bahcecioglu, Huseyin Ataseven

  • 1Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey. okpoyrazoglu@yahoo.com

Inflammation
|November 15, 2008
PubMed

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...