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Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Protein and Protein Structures

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...

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Updated: Jun 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Using support vector machines for prediction of protein structural classes based on discrete wavelet transform.

Jian-Ding Qiu¹, San-Hua Luo, Jian-Hua Huang

¹Institute for Advanced Study and Department of Chemistry, Nanchang University, Nanchang 330031, People's Republic of China. jdqiu@ncu.edu.cn

Journal of Computational Chemistry

|November 15, 2008

Summary

This study introduces a new method combining support vector machines and discrete wavelet transform to accurately predict protein structural classes, improving upon existing techniques.

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Last Updated: Jun 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Area of Science:

* Computational biology
* Bioinformatics
* Structural biology

Background:

* Protein secondary structure prediction is crucial for understanding protein structure and function.
* Incorporating sequence-order effects is key to improving predictive accuracy for protein structural classification.
* Existing methods face challenges in effectively utilizing sequence-order information.

Purpose of the Study:

* To develop a novel computational method for predicting protein structural classes.
* To enhance the accuracy of protein structural classification by integrating sequence-order effects.
* To evaluate the performance of the proposed prediction approach.

Main Methods:

* A hybrid approach combining Support Vector Machine (SVM) with Discrete Wavelet Transform (DWT).
* Application of the SVM-DWT method for protein structural class prediction.
* Performance evaluation using rigorous cross-validation tests.

Main Results:

* The proposed SVM-DWT method significantly improves the success rates of protein structural class prediction.
* The approach demonstrates enhanced accuracy compared to existing methods.
* Cross-validation results confirm the method's effectiveness.

Conclusions:

* The developed SVM-DWT method is a powerful tool for predicting protein structural classes.
* This approach offers a significant advancement in computational protein analysis.
* The method shows potential for predicting other protein attributes beyond structural classification.