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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Related Experiment Video

Updated: Jun 28, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Endothelial progenitor cells: implications for cardiovascular disease.

Sven Möbius-Winkler1, Robert Höllriegel, Gerhard Schuler

  • 1Department of Cardiology and Internal Medicine, University Leipzig - Heart Center Leipzig, Leipzig, Germany.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|November 15, 2008
PubMed
Summary

Endothelial progenitor cells (EPCs) from bone marrow aid vessel repair and are impaired in cardiovascular disease. Therapeutic EPC application shows promise for treating these conditions.

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

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Last Updated: Jun 28, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Endothelial progenitor cells (EPCs) originate in bone marrow and circulate.
  • EPCs are crucial for maintaining the endothelial cell layer.
  • EPC levels and function are diminished in cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review EPC characterization and bone marrow mobilization.
  • To discuss the role of EPCs in cardiovascular health and disease.
  • To highlight therapeutic applications of EPCs in clinical cardiovascular diseases.

Main Methods:

  • Literature review focusing on EPC biology and clinical studies.
  • Analysis of EPC mobilization, function, and therapeutic potential.
  • Synthesis of data on EPCs in various cardiovascular conditions.

Main Results:

  • Circulating EPC levels predict cardiovascular events and mortality.
  • Impaired EPCs are a hallmark of cardiovascular diseases.
  • Animal studies and human trials demonstrate beneficial effects of applied EPCs.

Conclusions:

  • EPCs are vital for endothelial repair and cardiovascular health.
  • Reduced EPCs indicate increased cardiovascular risk.
  • EPC-based therapies offer a promising treatment strategy for cardiovascular diseases.