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Gastric Phase of Digestion

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The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Ghrelin and gastric acid secretion.

Koji Yakabi¹, Junichi Kawashima, Shingo Kato

¹Department of Gastroentorlogy and Hepatology, Saitama Medical Center, Saitama Medical University, 1821 Kamoda Tsujido-machi, Kawagoe-city, Saitama 350-8550, Japan. kjyakabi@saitama-med.ac.jp

World Journal of Gastroenterology

|November 15, 2008

Summary

Ghrelin stimulates gastric acid secretion, involving histamine and the vagal nerve. This peptide may play a role in fasting or nighttime acid production, distinct from gastrin's postprandial role.

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Area of Science:

Gastroenterology
Endocrinology
Neuroscience

Background:

Ghrelin, a growth hormone-releasing peptide from the stomach, influences GH secretion, appetite, and body weight.
Ghrelin also stimulates gastric motility and gastric acid secretion.
Previous studies suggested ghrelin's acid secretion effects were comparable to histamine and gastrin, with vagal nerve involvement.

Purpose of the Study:

To investigate the mechanism of ghrelin-induced gastric acid secretion.
To clarify the role of histamine in ghrelin's action on acid secretion.
To explore potential synergistic interactions between ghrelin and gastrin.

Main Methods:

Administered ghrelin and measured gastric acid secretion in vivo.
Utilized vagotomy to assess the involvement of the vagal nerve.
Administered famotidine (H2 receptor antagonist) to evaluate histamine's role.
Measured histidine decarboxylase (HDC) mRNA levels in gastric mucosa.

Main Results:

Ghrelin significantly increased gastric acid secretion.
Vagotomy completely abolished ghrelin-induced acid secretion.
Famotidine completely inhibited ghrelin-induced acid secretion, contradicting previous findings.
Ghrelin injection increased HDC mRNA in the gastric mucosa, an effect blocked by vagotomy.
A synergistic effect of gastrin and ghrelin on gastric acid secretion was observed.

Conclusions:

Histamine is involved in ghrelin-induced gastric acid secretion.
The vagal nerve plays a crucial role in mediating ghrelin's effect on acid secretion.
Ghrelin may contribute to gastric acid secretion during fasting or nocturnal periods.