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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Published on: October 16, 2010

Pregnancy-associated breast cancer

Lital Keinan-Boker1, Liat Lerner-Geva, Bella Kaufman

  • 1Israel Center for Disease Control, Ministry of Health, Sheba Medical Center of Health Policy Research, Tel Hashomer, Israel. lkeinan@univ.haifa.ac.il

The Israel Medical Association Journal : IMAJ
|November 18, 2008
PubMed

The frequency of pregnancy-associated breast cancer, a rare but serious occurrence, may increase in light of the secular trends for lower parity in general and for older age at first full-term delivery in particular Data on PABC in individuals who are at high risk for breast cancer are limited. A computerized search of Pubmed showed that the reported incidence of PABC is 1:3000 pregnancies; it is often diagnosed at an advanced stage and its prognosis is inferior compared to non-PABC Carriers of mutations in the genes BRCA1/2 may present a specific high risk group for PABC especially at younger ages. Women treated with fertility treatment drugs may be at a higher risk for PABC as well.

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