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Updated: Jun 28, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Neuropathic pain in people treated for multibacillary leprosy more than ten years previously
Paul Saunderson1, Elizabeth Bizuneh, Ruth Leekassa
1American Leprosy Missions, Greenville, SC 29601, USA. psaunderson@leprosy.org
Objectives:
To identify patients with typical symptoms of neuropathic pain in a well-defined cohort of multibacillary patients being followed up as part of a relapse study in Ethiopia; to identify risk factors for the development of neuropathic pain.
Design:
96 patients who had completed MDT more than 10 years previously participated in the study, through a questionnaire.
Results:
28 (29%) had symptoms of neuropathic pain and it was reported as severe in 12. Because the past history of these subjects is well documented, a risk factor analysis was carried out. The presence of leprosy-related impairment was the only significant risk factor for neuropathic pain that was identified.
Conclusions:
Neuropathic pain is an important problem in a proportion of people previously treated for leprosy. Further research into the management of the condition is required.
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