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Related Concept Videos

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...

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Translation Efficiency Test Using Polysome Profiles Under Heat Stress
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Translation Efficiency Test Using Polysome Profiles Under Heat Stress

Published on: October 11, 2024

DNA stress checkpoint control and plant development.

Toon Cools1, Lieven De Veylder

  • 1Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Ghent, Belgium.

Current Opinion in Plant Biology
|November 18, 2008
PubMed
Summary

Plants possess DNA stress checkpoints to repair genome damage from environmental threats. These mechanisms arrest the cell cycle, highlighting unique plant adaptations for maintaining DNA integrity.

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Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
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Translation Efficiency Test Using Polysome Profiles Under Heat Stress
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Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
10:55

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

Published on: November 5, 2012

Area of Science:

  • Plant biology
  • Molecular biology
  • Genetics

Background:

  • Plants face constant environmental genotoxic stress due to their sessile nature.
  • Genome integrity is crucial for plant survival and reproduction.
  • Eukaryotic DNA integrity pathways are conserved, but plant-specific adaptations exist.

Purpose of the Study:

  • To investigate the unique DNA stress checkpoint mechanisms in plants.
  • To understand how plants regulate cell cycle control under DNA damage.
  • To explore plant-specific strategies for preserving genome integrity.

Main Methods:

  • Analysis of conserved DNA damage response pathways in plant models.
  • Comparative genomics to identify plant-specific genes involved in DNA repair.
  • Cell cycle analysis under induced DNA stress conditions.

Main Results:

  • Plants utilize DNA stress checkpoints to halt cell division upon detecting DNA damage.
  • Activation of DNA repair machinery is a key response to preserve genomic content.
  • Evidence suggests distinct regulatory mechanisms in plant cell cycle control compared to other eukaryotes.

Conclusions:

  • Plant DNA integrity maintenance involves conserved eukaryotic pathways with unique regulatory features.
  • Understanding these plant-specific mechanisms is vital for improving crop resilience.
  • Further research into plant DNA stress responses can uncover novel targets for genetic engineering.