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Influence of local anesthetics on ventilation
1Department of Anaesthesiology, University Hospital, Linköping University, Sweden.
Regional Anesthesia
|January 1, 1991
Summary
Local anesthetics like lidocaine, mepivacaine, and bupivacaine did not affect resting or hypercarbia-stimulated breathing. However, these drugs showed a slight stimulatory effect on ventilation during hypoxemia.
Area of Science:
- Anesthesiology
- Respiratory Physiology
Background:
- Local anesthetics are widely used in clinical practice.
- Their effects on ventilation, particularly under varying physiological conditions, require thorough understanding.
Purpose of the Study:
- To investigate the influence of intravenous lidocaine, mepivacaine, and bupivacaine on resting and stimulated ventilation.
- To assess the impact of these local anesthetics on ventilation during hypercarbia and hypoxemia.
Main Methods:
- Eighteen healthy volunteers received intravenous infusions of lidocaine, mepivacaine, or bupivacaine.
- Ventilatory parameters were measured at rest and during stimulated conditions (hypercarbia, hypoxemia) before and during drug infusion.
Main Results:
- Local anesthetics did not alter resting ventilation.
- Ventilation stimulated by hypercarbia remained unaffected by the tested local anesthetics.
- A slight increase in ventilation was observed during hypoxemia when local anesthetics were administered.
Conclusions:
- Intravenous lidocaine, mepivacaine, and bupivacaine do not significantly impair resting or hypercarbia-stimulated ventilation.
- These agents may have a mild stimulatory effect on respiratory drive under hypoxic conditions.