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Updated: Jun 28, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Dietary activators of Sirt1
Joanne S Allard1, Evelyn Perez, Sige Zou
1Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, National Institutes of Health, Baltimore, MD 21224, USA.
Abstract:
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
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