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Updated: Jun 28, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Equine odontoclastic tooth resorption and hypercementosis.

Carsten Staszyk¹, Astrid Bienert, Robert Kreutzer

¹Institute of Anatomy, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany. carsten.staszyk@tiho-hannover.de

Veterinary Journal (London, England : 1997)

|November 18, 2008

Summary

A painful equine dental disorder, equine odontoclastic tooth resorption and hypercementosis (EOTRH), involves tooth tissue changes. Research identified odontoclastic cells and a sequence of resorption and hypercementosis, proposing mechanical stress as a cause.

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Accessing the Cytotoxicity and Cell Response to Biomaterials

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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

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Published on: August 22, 2022

Area of Science:

Veterinary Dentistry
Equine Pathology

Background:

A painful dental disorder affecting aged horses, characterized by tooth tissue changes, has been recently documented.
The aetiopathogenesis of this syndrome remains poorly understood.

Purpose of the Study:

To investigate the pathological features of a painful dental disorder in aged horses.
To propose a term and investigate the aetiopathogenesis of this equine dental syndrome.

Main Methods:

Gross and microscopic examination of eighteen diseased teeth from eight horses.
Tartrate resistant acid phosphatase (TRAP) staining to identify odontoclastic cells.

Main Results:

Microscopic examination revealed the presence of odontoclastic cells in diseased equine teeth.
A chronological sequence of odontoclastic resorption followed by hypercementosis was demonstrated.
The term equine odontoclastic tooth resorption and hypercementosis (EOTRH) was proposed for this disorder.

Conclusions:

Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a distinct dental disorder in horses.
EOTRH shares similarities with dental syndromes in humans and cats.
Mechanical stress on the periodontal ligament is hypothesized as the initiating factor for EOTRH.