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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein and Protein Structures02:15

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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Updated: Jun 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

The protein structure initiative structural genomics knowledgebase.

Helen M Berman1, John D Westbrook, Margaret J Gabanyi

  • 1Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. berman@rcsb.rutgers.edu

Nucleic Acids Research
|November 18, 2008
PubMed
Summary
This summary is machine-generated.

The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB) centralizes structural biology data, including protein structures, functional annotations, and research publications. This resource aims to advance understanding of biological systems and disease for researchers.

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Area of Science:

  • Structural Biology
  • Genomics
  • Bioinformatics

Background:

  • The Protein Structure Initiative (PSI) has generated extensive structural genomics data.
  • A need exists to consolidate and disseminate this data for broader research application.
  • Existing resources may lack integrated access to diverse structural biology information.

Purpose of the Study:

  • To create a centralized knowledgebase (PSI SGKB) for PSI structural genomics data.
  • To facilitate the use of structural biology information for understanding biological systems and disease.
  • To bridge the gap between structural biology research and the biomedical community.

Main Methods:

  • Centralized access to Protein Data Bank (PDB) structures.
  • Integration of functional annotations and homology models.
  • Inclusion of protein target tracking and protocol information.
  • Searchable database of structural and methodological publications.
  • Collaboration with Nature Publishing Group for research content.

Main Results:

  • The PSI SGKB provides a unified platform for structural genomics data.
  • It offers access to protein structures, functional data, and research publications.
  • The knowledgebase includes target tracking, protocols, and DNA material availability.
  • It features a research library, editorials, news, and an events calendar.

Conclusions:

  • The PSI SGKB effectively transforms structural genomics efforts into accessible knowledge.
  • It serves as a vital resource for researchers in structural biology and biomedicine.
  • Free availability of resources promotes advancements in understanding biological systems and disease.