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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

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Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Related Experiment Video

Updated: Jun 28, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

Evolution of microRNA expression during human bronchial squamous carcinogenesis.

C Mascaux¹, J F Laes, G Anthoine

¹Institut Jules Bordet, Rue Héger-Bordet 1, B-1000 Brussels, Belgium.

The European Respiratory Journal

|November 18, 2008

Summary

MicroRNAs play a crucial role in early lung cancer development. Their altered expression patterns can help predict disease progression and potentially enable early lung cancer detection.

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Last Updated: Jun 28, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue

Published on: November 21, 2023

Area of Science:

Molecular Biology
Oncology
Genetics

Background:

MicroRNAs are key regulators of gene expression involved in various cancers.
Their specific role in the early stages of bronchial carcinogenesis remains largely unexplored.

Purpose of the Study:

To investigate the differential expression of microRNAs during bronchial carcinogenesis.
To assess the potential of microRNAs as biomarkers for early lung cancer detection.

Main Methods:

Analysis of 60 bronchial biopsies across different stages of carcinogenesis using fluorescence bronchoscopy.
Quantification of 69 microRNAs to identify differentially expressed candidates.

Main Results:

69 microRNAs showed differential expression during bronchial carcinogenesis.
Specific microRNAs exhibited linear or stage-dependent expression changes.
MicroRNA expression patterns effectively predicted histological classifications, distinguishing low- and high-grade lesions.

Conclusions:

MicroRNAs are implicated in bronchial carcinogenesis from its earliest stages.
MicroRNA expression profiling offers a promising tool for the early detection of lung cancer.