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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Respiratory Syncytial Virus Disease01:29

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Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Updated: Jun 28, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

High-sensitive C-reactive protein is associated with reduced lung function in young adults.

F Rasmussen1, D Mikkelsen, R J Hancox

  • 1Dept of Respiratory Diseases, Odense University Hospital, 5000 Odense C, Denmark. Finn.Rasmussen@dadlnet.dk

The European Respiratory Journal
|November 18, 2008
PubMed
Summary

Systemic inflammation, indicated by C-reactive protein (CRP), is linked to reduced lung function in young adults. Higher CRP levels predict a greater decline in lung function over time.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Epidemiology

Background:

  • Systemic inflammation is linked to reduced lung function.
  • The relationship between low-grade inflammation and lung function decline is not well understood.
  • C-reactive protein (CRP) is a marker of systemic inflammation.

Purpose of the Study:

  • To assess the association between high-sensitive C-reactive protein (hs-CRP) and spirometric lung function.
  • To determine if low-grade inflammation predicts future lung function decline in young adults.

Main Methods:

  • A population-based cohort study of approximately 1,000 Danes aged 20 years.
  • Measurement of hs-CRP levels and spirometric lung function (FEV1, FVC).
  • Multiple regression analysis adjusted for relevant covariates including sex, BMI, fitness, smoking, and asthma.

Main Results:

  • Higher CRP levels were associated with a greater decline in FEV1 and FVC between ages 20 and 29.
  • In males, the highest CRP quintile showed an average FEV1 decline of 23 mL/year vs. 1.6 mL/year in the lowest quintile.
  • In females, the highest CRP quintile showed an average FEV1 decline of 6.2 mL/year vs. an increase of 1.8 mL/year in the lowest quintile.

Conclusions:

  • Elevated hs-CRP levels in young adulthood are associated with subsequent lung function decline.
  • Low-grade systemic inflammation may impair lung function independently of smoking, obesity, fitness, or asthma.
  • These findings suggest a potential role for anti-inflammatory strategies in preserving lung health.