High-sensitive C-reactive protein is associated with reduced lung function in young adults
F Rasmussen1, D Mikkelsen, R J Hancox
1Dept of Respiratory Diseases, Odense University Hospital, 5000 Odense C, Denmark. Finn.Rasmussen@dadlnet.dk
The European Respiratory Journal
|November 18, 2008
Summary
Systemic inflammation, indicated by C-reactive protein (CRP), is linked to reduced lung function in young adults. Higher CRP levels predict a greater decline in lung function over time.
Area of Science:
- Pulmonary Medicine
- Immunology
- Epidemiology
Background:
- Systemic inflammation is linked to reduced lung function.
- The relationship between low-grade inflammation and lung function decline is not well understood.
- C-reactive protein (CRP) is a marker of systemic inflammation.
Purpose of the Study:
- To assess the association between high-sensitive C-reactive protein (hs-CRP) and spirometric lung function.
- To determine if low-grade inflammation predicts future lung function decline in young adults.
Main Methods:
- A population-based cohort study of approximately 1,000 Danes aged 20 years.
- Measurement of hs-CRP levels and spirometric lung function (FEV1, FVC).
- Multiple regression analysis adjusted for relevant covariates including sex, BMI, fitness, smoking, and asthma.
Main Results:
- Higher CRP levels were associated with a greater decline in FEV1 and FVC between ages 20 and 29.
- In males, the highest CRP quintile showed an average FEV1 decline of 23 mL/year vs. 1.6 mL/year in the lowest quintile.
- In females, the highest CRP quintile showed an average FEV1 decline of 6.2 mL/year vs. an increase of 1.8 mL/year in the lowest quintile.
Conclusions:
- Elevated hs-CRP levels in young adulthood are associated with subsequent lung function decline.
- Low-grade systemic inflammation may impair lung function independently of smoking, obesity, fitness, or asthma.
- These findings suggest a potential role for anti-inflammatory strategies in preserving lung health.
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