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Triacetin: a potential parenteral nutrient.

J W Bailey1, M W Haymond, J M Miles

  • 1Department of Medicine, Mayo Medical School, Rochester, Minnesota 55905.

JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1991
PubMed
Summary
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Triacetin infusion in dogs showed no toxicity, increasing ketone bodies and energy expenditure while decreasing glucose clearance. These findings suggest triacetin

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Veterinary Medicine

Background:

  • Triacetin, a water-soluble triglyceride of acetate, is being investigated for its metabolic effects.
  • Understanding triacetin's impact on glucose and ketone body metabolism is crucial for its potential therapeutic applications.

Purpose of the Study:

  • To evaluate the metabolic effects and safety of triacetin infusion in dogs.
  • To quantify ketone body and glucose production rates during triacetin administration.
  • To assess changes in energy expenditure and glucose clearance.

Main Methods:

  • Mongrel dogs were infused with triacetin at isocaloric and hypercaloric rates.
  • Ketone body and glucose production were measured using isotopic tracers ([13C2] acetoacetate and [3H]glucose).

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  • Energy expenditure was determined, and plasma metabolite concentrations were monitored.

    • Main Results:

    • Triacetin infusion was well-tolerated without acute toxicity at both infusion rates.
    • Plasma acetate concentrations increased significantly, particularly at the hypercaloric rate.
    • Ketone body concentrations and production increased, while glucose clearance decreased significantly in both groups.

    Conclusions:

    • Triacetin can be safely administered at high rates in dogs.
    • Triacetin administration leads to increased ketone body production and may compete with glucose metabolism.
    • Further research is warranted to explore triacetin's potential as a parenteral nutrient.