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Updated: Jun 28, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Retrospective study of cranial strain pattern prevalence in a healthy population
Elena M Timoshkin1, Mark Sandhouse
1Department of Osteopathic Principles and Practice, Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, Florida, USA. timoshki@nsu.nova.edu
Context:
Research studies have associated cranial strain patterns with a variety of neurologic disorders. However, baseline data on the prevalence of such patterns in a healthy population is lacking.
Objective:
To determine the prevalence of cranial strain patterns in healthy subjects.
Methods:
A retrospective analysis of cranial strain findings from healthy subjects who participated in two previous research projects. Data were collected for the following cranial strain patterns: torsion (left or right), sidebending rotation (left or right), lateral (left or right), and vertical (superior or inferior).
Results:
Data from 142 healthy subjects--119 women and 23 men with a mean age of 24.5 years--were analyzed. Torsion and sidebending rotation were the most common cranial strain patterns observed, comprising 72% of all identified patterns. The most prevalent patterns when stratified by the side of dysfunction were right torsion (31%), left sidebending rotation (23%), and left lateral (19%). Left sidebending rotation with right torsion (17%); left lateral, left sidebending rotation, and right torsion (14%); and right sidebending rotation with right torsion (11%) were the most common combinations of cranial stain patterns.
Conclusion:
Although the present study identified common cranial strain patterns in a healthy population, future studies with broader patient populations and multiple observers are needed to confirm and further define these findings.
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