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Related Experiment Video

Updated: Jun 28, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Frailty and muscle function: role for testosterone?

U Srinivas-Shankar¹, F Wu

¹Department of Endocrinology, University of Manchester, Manchester Royal Infirmary, Manchester, UK.

Frontiers of Hormone Research

|November 18, 2008

Summary

This summary is machine-generated.

Physical frailty in older men is linked to declining testosterone. Testosterone supplementation may improve muscle mass, strength, and physical performance, offering a potential treatment avenue.

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Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

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Last Updated: Jun 28, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Area of Science:

Gerontology
Endocrinology
Geriatric Medicine

Background:

Frailty is a clinical syndrome in older adults, marked by reduced physiological reserve and increased risk of adverse outcomes like falls, fractures, hospitalization, and mortality.
Aging is associated with declining testosterone levels, which contributes to sarcopenia (muscle loss) and decreased strength.
Understanding the interplay between aging, frailty, and hormonal changes is crucial for developing effective interventions.

Purpose of the Study:

To review the clinical syndrome of frailty in older men.
To examine the relationship between frailty and falling testosterone levels.
To evaluate the effects of testosterone supplementation on muscle mass, strength, and physical performance in older men.

Main Methods:

Literature review of studies on frailty, testosterone levels, and testosterone supplementation in older men.
Analysis of data concerning the impact of testosterone on muscle mass, strength, and physical function.
Synthesis of findings from both healthy and unhealthy/frail older male populations.

Main Results:

Testosterone supplementation demonstrates anabolic effects on muscle, potentially improving muscle mass and strength.
Evidence suggests benefits in physical performance for some older men, though results vary between healthy and frail individuals.
The review consolidates current understanding of testosterone's role in mitigating frailty-related decline.

Conclusions:

Frailty is a significant concern in aging populations, influenced by factors including hormonal changes.
Testosterone supplementation is a promising therapeutic strategy for addressing sarcopenia and improving physical function in frail older men.
Further research is warranted to optimize testosterone therapy for different subgroups of older men experiencing frailty.