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Related Experiment Video

Updated: Jun 28, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Testosterone and prostate safety.

A Morgentaler¹, C Schulman

¹Division of Urology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USA.

Frontiers of Hormone Research

|November 18, 2008

Summary

This summary is machine-generated.

Testosterone therapy does not increase prostate cancer risk. Low testosterone levels, however, are linked to higher prostate cancer risk, necessitating regular monitoring for men on testosterone therapy.

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Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

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Last Updated: Jun 28, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Area of Science:

Endocrinology
Urology
Oncology

Background:

Historical belief: Higher testosterone (T) promotes prostate tissue growth.
Recent evidence challenges this long-standing assumption regarding T therapy risks.

Purpose of the Study:

To evaluate the association between testosterone therapy and prostate health.
To assess the risk of prostate cancer and benign prostatic hyperplasia (BPH) with T therapy.

Main Methods:

Review of smaller clinical trials and population-based longitudinal studies.
Analysis of data on serum T, intraprostatic T, and dihydrotestosterone (DHT) levels.

Main Results:

Studies consistently fail to support increased prostate cancer risk or BPH exacerbation with T therapy.
Exogenous T does not appear to increase intraprostatic T or DHT, suggesting a saturation effect.
Low serum T is associated with increased prostate cancer risk and more aggressive features.

Conclusions:

Available evidence indicates testosterone therapy is safe for the prostate.
Regular prostate cancer monitoring is recommended for men on T therapy due to overlapping risk factors.