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Updated: Jun 28, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Evaluation of first-trimester tricuspid regurgitation for Down syndrome screening
1Obstetrix Medical Group of Colorado, Perinatal Nurse Practitioner Services, Presbyterian/St. Luke's Medical Center, Denver, CO 80218, USA. deborah_mcgee@pediatrix.com
Abstract:
Screening for Down syndrome has become an integral part of prenatal care. In recent years, there has been significant interest in first-trimester screening methods. Increased nuchal translucency in the first trimester of pregnancy has been identified as a marker for chromosomal anomalies and congenital cardiac disease. In addition, research has identified a correlation between tricuspid regurgitation, diagnosed by pulsed-wave Doppler ultrasonography, in aneuploid fetuses between 11 and 13 + 6 weeks' gestation. This article provides a brief historical overview of screening for aneuploidy and examines the emerging trend and pitfalls of first-trimester screening.
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