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Related Experiment Videos

Hepatitis C: prevention and treatment.

P J Dolan1, R M Skibba, R C Hagan

  • 1University of Kansas School of Medicine, Wichita.

American Family Physician
|April 1, 1991
PubMed
Summary

Hepatitis C virus (HCV) was identified in 1988, leading to new diagnostic tests and treatments. Blood screening for HCV significantly reduces transfusion risks, while alpha interferon offers therapeutic options for infected individuals.

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Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis B screening revealed non-A, non-B hepatitis as a major post-transfusion concern.
  • The causative agent of non-A, non-B hepatitis remained unknown until 1988.

Purpose of the Study:

  • To report the identification of the hepatitis C virus (HCV).
  • To discuss the implications of HCV for public health and transfusion medicine.

Main Methods:

  • Identification of the hepatitis C virus.
  • Development and approval of an antibody assay for HCV detection.

Main Results:

  • An estimated 150,000 new hepatitis C cases occur annually.
  • Hepatitis C leads to chronic liver disease in 50% of cases and 15,000 new cirrhosis cases yearly.
  • An HCV antibody assay was approved in 1990.

Conclusions:

  • Widespread donor blood screening with the new assay is expected to decrease transfusion-associated hepatitis C.
  • Alpha interferon therapy presents a potential treatment for existing hepatitis C infections, offering cure or palliation.

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