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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Opioids in musculoskeletal pain]
1Klinik für Anästhesiologie und operative Intensivmedizin , Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Deutschland. leonie.siegel@charite.de
Zeitschrift Fur Rheumatologie
|November 18, 2008
Summary
Opioids effectively manage severe pain but their use for chronic non-cancer pain (CNCP) is debated due to side effects and prescription challenges. This review explores opioid roles in rheumatic diseases and their peripheral pain and inflammation effects.
Area of Science:
- Pharmacology
- Rheumatology
- Pain Management
Context:
- Opioids are potent analgesics for severe pain, increasingly considered for chronic non-cancer pain (CNCP).
- Chronic rheumatic diseases, including low back pain and arthritis, are primary causes of CNCP.
- Opioid use in CNCP remains controversial due to side effects (tolerance, addiction, withdrawal) and prescription complexities.
Purpose:
- To provide an overview of opioid use in chronic rheumatic diseases.
- To outline the peripheral effects of opioids on pain and inflammation in rheumatic conditions.
- To note the anticipated release of a national guideline for opioid use in CNCP.
Summary:
- Opioids are powerful pain relievers, established for severe pain but facing controversy in chronic non-cancer pain (CNCP) management.
- Chronic rheumatic diseases are major contributors to CNCP, prompting investigation into opioid efficacy and risks.
- The article discusses opioid peripheral actions on pain and inflammation in rheumatic diseases, anticipating a new national guideline.
Impact:
- Informs clinical practice regarding opioid use in chronic rheumatic pain.
- Highlights the need for balanced consideration of opioid benefits versus risks.
- Contributes to the understanding of opioid mechanisms in inflammatory rheumatic conditions.
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