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Invasive, paediatric, vaccine strains of Streptococcus pneumoniae: are there differences in clinical characteristics?

Birger Trollfors1, Stefan Berg, Erik Backhaus

  • 1Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden. birger.trollfors@vgregion.se

Scandinavian Journal of Infectious Diseases
|November 18, 2008
PubMed

Insights

Invasive pneumococcal infections in adults show varied clinical features based on serogroup. The 7-valent pneumococcal conjugate vaccine may not significantly alter these characteristics in adults.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Vaccinology

Background:

  • Invasive pneumococcal infections (IPIs) pose a significant public health challenge.
  • Serogroup classification is crucial for understanding IPI epidemiology and vaccine impact.

Purpose of the Study:

  • To compare the clinical characteristics of IPIs caused by different pneumococcal serogroups in adults.
  • To evaluate the potential impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on IPI clinical presentation in adults.

Main Methods:

  • Retrospective analysis of 777 adult IPI cases.
  • Categorization of isolates into 'invasive', 'paediatric', and 'other' serogroups.
  • Comparison of clinical features including pneumonia incidence, patient demographics, comorbidities, and case-fatality rates.

Main Results:

  • 'Invasive' serogroups (1, 7) were associated with higher pneumonia rates and occurred in younger, healthier patients with lower case-fatality rates compared to 'paediatric' (6, 9, 14, 19, 23) and 'other' serogroups.
  • The 'paediatric' and 'other' serogroup categories exhibited similar clinical profiles.
  • Serotypes included in PCV7 showed clinical characteristics comparable to non-vaccine types.

Conclusions:

  • Clinical presentation of IPIs in adults varies by serogroup.
  • Widespread use of PCV7 is unlikely to substantially alter the clinical spectrum of IPIs in the adult population.
  • Further research into adult IPIs and broader-spectrum vaccines is warranted.

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