Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serial fractional exhaled nitric oxide measurements at and off work may help to identify immunologic occupational asthma in cases with complex exposures.

Respiratory physiology & neurobiology·2023
Same author

Sputum Inflammatory Patterns Are Associated With Distinct Clinical Characteristics in Patients with Occupational Asthma Independently of the Causal Agent.

Journal of investigational allergology & clinical immunology·2022
Same author

Expression of DNA mismatch repair proteins in melanoma patients treated with immune checkpoint inhibitors.

Journal of cancer research and clinical oncology·2022
Same author

Protein expression of prognostic genes in primary melanoma and benign nevi.

Journal of cancer research and clinical oncology·2021
Same author

[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma - An Expert Consensus Paper].

Pneumologie (Stuttgart, Germany)·2021
Same author

Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.

Clinical and experimental dermatology·2021
Same journal

Pneumologie (Stuttgart, Germany)·2026
Same journal

Aerosol therapy during noninvasive ventilation (NIV) and nasal high-flow therapy (HFT): current technology and consensus-based recommendations.

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Correction: Pharmacotherapy for Tobacco Dependence: Implementation of the Current G-BA Resolution - Erratum: Information from Section E3 of the DGP regarding the G-BA Resolution].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Pharmacotherapy for Tobacco Dependence: Implementation of the Current G-BA Resolution - Information from Section E3 of the DGP regarding the G-BA Resolution].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Acute lung failure].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[The internet as a source of information for patients with sarcoidosis].

Pneumologie (Stuttgart, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

[Occupational allergies to phytase].

V van Kampen1, R Merget, T Brüning

  • 1BGFA - Forschungsinstitut für Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung, Institut der Ruhr-Universität Bochum. kampen@bgfa.de

Pneumologie (Stuttgart, Germany)
|November 18, 2008
PubMed
Summary
This summary is machine-generated.

Occupational exposure to phytase (enzyme dust) can cause specific airway sensitization in workers. Studies confirm an immunologic mechanism behind these respiratory allergies, supported by various diagnostic tests.

More Related Videos

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Related Experiment Videos

Last Updated: Jun 28, 2026

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Area of Science:

  • Enzymology
  • Occupational Health
  • Immunology

Context:

  • Phytases are enzymes used as feed supplements to improve nutrient absorption in animals.
  • Occupational exposure to enzyme dusts is a known cause of respiratory allergies.
  • Phytate is an indigestible compound in plant materials.

Purpose:

  • To review and evaluate literature data on occupational airway sensitization caused by phytases.
  • To assess the evidence for immunologic mechanisms in phytase-induced respiratory allergies.
  • To consolidate findings on the diagnostic criteria for phytase sensitization.

Summary:

  • Phytases, used in animal feed, can lead to occupational airway sensitization.
  • Multiple studies demonstrate specific airway sensitization due to phytase exposure.
  • Consistent findings from skin prick tests, IgE antibody detection, and challenge tests indicate an immunologic basis.

Impact:

  • Highlights the occupational health risks associated with phytase enzyme dust.
  • Provides a basis for developing preventive measures and workplace safety guidelines.
  • Contributes to understanding enzyme-induced allergies in industrial settings.