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The effect of familial aggregation on the children with primary nocturnal enuresis

Qing Wei Wang1, Jian Guo Wen, Qing Hua Zhu

  • 1Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Neurourology and Urodynamics
|November 18, 2008
PubMed

Insights

Familial aggregation significantly impacts pediatric nocturnal enuresis (NE), leading to more severe symptoms and bladder dysfunction in affected children. Early urodynamic studies are recommended for diagnosis and treatment.

Area of Science:

  • Pediatric Urology
  • Nephrology
  • Genetics

Background:

  • Nocturnal enuresis (NE) is a common condition in children.
  • Familial aggregation suggests a genetic component in some NE cases.
  • Understanding the impact of familial aggregation is crucial for effective management.

Purpose of the Study:

  • To evaluate the effect of familial aggregation on children with nocturnal enuresis (NE).
  • To assess nocturnal urine output, bladder function, and arousal patterns in children with NE.
  • To compare outcomes between familial aggregation NE (FPNE) and sporadic NE (SPNE).

Main Methods:

  • Inclusion of 45 children with FPNE, 70 with SPNE, and 10 controls.
  • Utilized questionnaires for arousal from sleep (AS scores), bladder diaries, and daytime urodynamic studies.
  • Analyzed data based on familial history of NE across three generations.

Main Results:

  • FPNE cases showed higher incidences of severe NE, non-monosymptomatic NE, small bladder, daytime detrusor overactivity, and urodynamic functional bladder outflow obstruction compared to SPNE.
  • Nocturnal urine output and AS scores were higher, and maximal voided volume was smaller in both NE groups versus controls.
  • Maximum cystometric capacity significantly decreased from control to FPNE groups.

Conclusions:

  • Familial aggregation significantly influences the severity and bladder dysfunction in pediatric NE.
  • FPNE is associated with more severe symptoms and poorer bladder function.
  • Urodynamic studies are beneficial for diagnosing and treating children with FPNE.
Abstract

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