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Related Experiment Video

Updated: Jun 28, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Transcatheter valve repair and replacement.

Susheel Kodali¹, Allan Schwartz

¹Columbia University Medical Center, New York, New York 10032, USA. sk2427@columbia.edu

Annual Review of Medicine

|November 18, 2008

Summary

Transcatheter therapy for valvular heart disease is rapidly advancing, with devices for aortic stenosis and mitral regurgitation entering clinical trials. These trials will assess long-term outcomes compared to traditional surgery.

Area of Science:

Cardiology
Interventional Cardiology
Biomedical Engineering

Background:

Valvular heart disease (VHD) affects millions globally, necessitating innovative treatment options.
Traditional surgical valve repair/replacement carries significant risks, driving demand for less invasive alternatives.
Transcatheter valve interventions represent a paradigm shift in VHD management.

Purpose of the Study:

To review the current landscape of transcatheter valve therapies for VHD.
To summarize the status of devices for aortic stenosis and mitral regurgitation.
To highlight the significance of ongoing randomized clinical trials.

Main Methods:

Review of current literature and clinical trial data.
Analysis of device development for percutaneous pulmonary, aortic, and mitral valve interventions.

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Synthesis of information on the progression of transcatheter devices into clinical trials.

Main Results:

Numerous transcatheter devices have been developed for VHD.
Several devices are currently undergoing rigorous evaluation in randomized clinical trials.
Ongoing trials are crucial for understanding long-term durability and comparative effectiveness.

Conclusions:

The field of transcatheter valve therapy is evolving quickly.
Clinical trials are essential for validating the safety and efficacy of these novel treatments.
Transcatheter approaches hold significant promise for improving VHD patient outcomes.