Multiple myeloma manifesting as an intraventricular brain tumor
Joo-Hun David Eum1, Astrid Jeibmann, Werner Wiesmann
1Department of Neurosurgery, University Hospital of Münster, Germany.
Abstract:
Primary intracerebral manifestation of multiple myeloma is rare and usually arises from the meninges or brain parenchyma. The authors present a case of multiple myeloma primarily manifesting within the lateral ventricle. A 67-year-old man was admitted with headache accompanied by slowly progressing right hemiparesis. Magnetic resonance imaging showed a large homogeneous contrast-enhancing intraventricular midline mass and hydrocephalus. The tumor was completely resected, and histopathological examination revealed plasmacytoma. After postoperative radio- and chemotherapy, vertebral osteolysis was detected as a secondary manifestation of multiple myeloma.
Insights
Primary brain tumors from multiple myeloma are rare. This case highlights a lateral ventricle plasmacytoma, a unique intracerebral manifestation of multiple myeloma, successfully treated with surgery and adjuvant therapy.
Area of Science:
- Neurology
- Oncology
- Neurosurgery
Background:
- Multiple myeloma rarely presents as a primary intracerebral tumor.
- Intracerebral lesions typically involve the meninges or brain parenchyma.
Observation:
- A 67-year-old male presented with headache and progressive right hemiparesis.
- MRI revealed a large, contrast-enhancing intraventricular mass causing hydrocephalus.
Findings:
- Surgical resection confirmed the mass as a plasmacytoma.
- Histopathology identified it as a primary intracerebral manifestation of multiple myeloma.
- Vertebral osteolysis was detected post-treatment, indicating secondary multiple myeloma.
Implications:
- This case expands the understanding of rare neurological presentations of multiple myeloma.
- Highlights the importance of considering systemic disease in primary brain tumors.
- Demonstrates successful management of intraventricular plasmacytoma.
