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Published on: July 11, 2025
Novel therapies for the prevention of malaria
1Medical Research Council (UK) The Gambia MRC Laboratories, Fajara, PO Box 273, Banjul, The Gambia. kbojang@mrc.gm
Background:
Malaria continues to exact a huge toll on the health of residents of endemic countries. Thus, new approaches to prevention and treatment are needed.
Objective:
To provide an update on novel therapies for the prevention of malaria.
Methods:
Systematic MEDLINE search from 1956 to 2008 using the search term 'malaria' (with the subheadings 'intermittent preventive treatment', 'mass drug administration', 'chemotherapy', 'artemisinin-based combination therapy' and 'home-based management of malaria').
Conclusions:
Chemoprophylaxis is used as a short-term protective measure for non-immune visitors to malaria-endemic countries. However, in malaria-endemic areas, chemoprophylaxis has not been implemented widely because of concerns related to sustainability, cost-effectiveness, appropriate delivery systems and development of drug resistance. Intermittent preventive treatment, a novel approach to malaria control, has the potential to provide some of the benefits of sustained chemoprophylaxis without some of its drawbacks.
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