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Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia
Fabiana Bernardi1, Francieli Guolo, Thaize Bortolin
1Experimental Physiopathology Laboratory, University of the Extreme South Catarinense, SC, Brazil.
Aim:
Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia.
Methods:
We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-10.
Results:
Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure.
Conclusions:
We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.
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